Endocrine Abstracts

This talk aims to explain:• What is proton beam therapy (PBT)• How it is delivered• Clinical indications for PBT• Evidence for its use• Challenges• UK service – current and future...

Background: Distant metastases develop in approximately 5–10% of patients with differentiated thyroid cancer (DTC). Nearly 70% of this subset will become radioiodine refractory (RAI-R) with a poor prognosis. Recently, the multikinase inhibitors (MKIs) showed promising results of treating these patients. It has become crucial to identify RAI-R DTC early. This study was conducted to identify the predictors of RAI-R disease in patients with distant metastasis secondary to d...

Aims: Although rare, craniopharyngiomas are the commonest suprasellar tumour in childhood. Despite high overall survival, children and young people <19 years with craniopharyngiomas are at risk of multiple relapses and long-term tumour- and treatment-related morbidity. We sought to provide, for the first time, a national standard for best practice based on currently available evidence for the assessment, treatment and follow-up of paediatric craniopharyngiomas under the au...

Objectives: In 2010 we piloted a national multidisciplinary (MDT), meeting virtually to improve management of rare suprasellar (HPAT) tumours. In 2014 we reported centralised treatment decision-making in craniopharyngioma and now wished to examine whether centre based management of idiopathic thickening of the pituitary stalk (iTPS) differs and can be streamlined by wider debate. This might also inform current commissioned BSPED and CCLG guidance.Methods...

Background: Childhood tumours of the hypothalamic pituitary axis (HPATs) are very rare and hence any single centre experience is limited. Without evidence-based guidance, treatment is individualised on a case basis. Survival rates are high, but at the expense of significant morbidity. Centralised care or wider multi-professional consultation may improve neuroendocrine and visual outcomes.Objective and hypotheses: 1. To facilitate multi-professional dial...